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norskBlar i forfatter "Butler, Christopher C."
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Are Patient Views about Antibiotics Related to Clinician Perceptions, Management and Outcome? A Multi-Country Study in Outpatients with Acute Cough
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: Outpatients with acute cough who expect, hope for or ask for antibiotics may be more unwell, benefit more from antibiotic treatment, and be more satisfied with care when they are prescribed antibiotics. Clinicians may not accurately identify those patients. Objective: To explore whether patient views (expecting, hoping for or asking for antibiotics) are associated with illness presentation ... -
Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: Secondary analysis of a randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)<i>Background</i> - C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible.<br><br> <i>Aim</i> - To investigate the associations between presenting features and antibiotic prescribing in patients with ... -
C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: The PACE RCT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03)Background - Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed antibiotics, but these may not be beneficial, and they can cause side effects and increase the risk of subsequent resistant infections. Point-of-care tests (POCTs) could safely reduce inappropriate antibiotic prescribing and antimicrobial resistance.<p> ... -
C-reactive protein-guided antibiotic prescribing for COPD exacerbations: A qualitative evaluation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)Background - Antibiotics are prescribed to >70% of patients presenting in primary care with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The PACE randomised controlled trial found that a C-reactive protein point-of-care test (CRP-POCT) management strategy for AECOPD in primary care resulted in a 20% reduction in patient-reported antibiotic consumption over 4 weeks.<p> <p>Aim ... -
Clinical Features and C-Reactive Protein as Predictors of Bacterial Exacerbations of COPD.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-01)Introduction: Identifying predictors of bacterial and viral pathogens in sputum from patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) may help direct management.<p> <p>Methods: We used data from a trial evaluating a C-reactive protein (CRP) point of care guided approach to managing COPD exacerbations in primary care. We used regression analyses to identify ... -
Clinical influences on antibiotic prescribing decisions for lower respiratory tract infection: a nine country qualitative study of variation in care.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)There is variation in antibiotic prescribing for lower respiratory tract infections (LRTI) in primary care that does not benefit patients. This study aims to investigate clinicians' accounts of clinical influences on antibiotic prescribing decisions for LRTI to better understand variation and identify opportunities for improvement. Multi country qualitative interview study. Semi-structured interviews ... -
General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): Study protocol for a randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)Background: <br>Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may not always be appropriate and may cause harm. C-reactive protein (CRP) is an acute-phase biomarker that can be rapidly measured at the point of care and may predict benefit from antibiotic treatment in AECOPD. It is not clear ... -
Understanding variation in primary medical care: a nine-country qualitative study of clinicians' accounts of the non-clinical factors that shape antibiotic prescribing decisions for lower respiratory tract infection.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)There is a wide variation between European countries in antibiotic prescribing for patients in primary care with lower respiratory tract infection (LRTI) that is not explained by case mix and clinical factors alone. Variation in antibiotic prescribing that is not warranted by differences in illness and clinical presentation may increase selection of resistant organisms, contributing to the problem ...
